Tuning Microparticle Porosity during Single Needle Electrospraying Synthesis via a Non-Solvent-Based Physicochemical ApproachReportar como inadecuado




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1

College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China

2

Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China

3

Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK





*

Author to whom correspondence should be addressed.



Academic Editor: Michael D. Guiver

Abstract Porous materials, especially microparticles MP, are utilized in almost every field of engineering and science, ranging from healthcare materials drug delivery to tissue engineering to environmental engineering biosensing to catalysis. Here, we utilize the single needle electrospraying technique as opposed to complex systems currently in development to prepare a variety of polyε-caprolactone PCL MPs with diverse surface morphologies variation in pore size from 220 nm to 1.35 µm and architectural features e.g., ellipsoidal, surface lamellar, Janus lotus seedpods and spherical. This is achieved by using an unconventional approach exploiting physicochemical properties of a series of non-solvents as the collection media via a single step. Sub-micron pores presented on MPs were visualized by electron microscopy demonstrating a mean MP size range of 7–20 μm. The present approach enables modulation in morphology and size requirements for specific applications e.g., pulmonary delivery, biological scaffolds, multi-stage drug delivery and biomaterial topography enhancement. Differences in static water contact angles were observed between smooth and porous MP-coated surfaces. This reflects the hydrophilic-hydrophobic properties of these materials. View Full-Text

Keywords: microparticles; porous; shape; polyε-caprolactone; tuned microparticles; porous; shape; polyε-caprolactone; tuned





Autor: Yuan Gao 1,2, Yuntong Bai 1,2, Ding Zhao 1,2, Ming-Wei Chang 1,2,* , Zeeshan Ahmad 3 and Jing-Song Li 1,2

Fuente: http://mdpi.com/



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