Design and Performance of a Multi-Point Scan Confocal MicroendoscopeReportar como inadecuado




Design and Performance of a Multi-Point Scan Confocal Microendoscope - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

College of Optical Sciences, University of Arizona, 1630 E. University Blvd., Tucson, AZ 85721, USA

2

Department of Medical Imaging, College of Medicine, University of Arizona, PO Box 245067, Tucson, AZ 85724, USA





*

Author to whom correspondence should be addressed.



Abstract Confocal fluorescence microendoscopy provides high-resolution cellular-level imaging via a minimally invasive procedure, but requires fast scanning to achieve real-time imaging in vivo. Ideal confocal imaging performance is obtained with a point scanning system, but the scan rates required for in vivo biomedical imaging can be difficult to achieve. By scanning a line of illumination in one direction in conjunction with a stationary confocal slit aperture, very high image acquisition speeds can be achieved, but at the cost of a reduction in image quality. Here, the design, implementation, and experimental verification of a custom multi-point aperture modification to a line-scanning multi-spectral confocal microendoscope is presented. This new design improves the axial resolution of a line-scan system while maintaining high imaging rates. In addition, compared to the line-scanning configuration, previously reported simulations predicted that the multi-point aperture geometry greatly reduces the effects of tissue scatter on image quality. Experimental results confirming this prediction are presented. View Full-Text

Keywords: confocal microscopy; microendoscopy; endomicroscopy; optical biopsy; multi-point imaging; Nipkow confocal microscopy; microendoscopy; endomicroscopy; optical biopsy; multi-point imaging; Nipkow





Autor: Matthew D. Risi 1,2, Houssine Makhlouf 1,2, Andrew R. Rouse 1,2, Anthony A. Tanbakuchi 1,2 and Arthur F. Gmitro 1,2,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados