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1

Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA

2

Christian Brothers High School, 5900 Walnut Grove Road, Memphis, TN 38120, USA





*

Author to whom correspondence should be addressed.



Abstract G protein-coupled receptors GPCRs comprise a large class of transmembrane proteins that play critical roles in both normal physiology and pathophysiology. These critical roles offer targets for therapeutic intervention, as exemplified by the substantial fraction of current pharmaceutical agents that target members of this family. Tremendous contributions to our understanding of GPCR structure and dynamics have come from both indirect and direct structural characterization techniques. Key features of GPCR conformations derived from both types of characterization techniques are reviewed. View Full-Text

Keywords: G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling G protein-coupled receptor; GPCR; structure; crystallography; NMR; modeling





Autor: Abby L. Parrill 1,* and Debra L. Bautista 2

Fuente: http://mdpi.com/



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