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Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA





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Abstract Drug addiction is a chronic illness characterized by high rates of relapse. Relapse to drug use can be triggered by re-exposure to drug-associated cues, stressful events, or the drug itself after a period of abstinence. Pharmacological intervention to reduce the impact of relapse-instigating factors offers a promising target for addiction treatment. Growing evidence has implicated an important role of the orexin-hypocretin system in drug reward and drug-seeking, including animal models of relapse. Here, we review the evidence for the role of orexins in modulating reward and drug-seeking in animal models of addiction and the potential for orexin receptors as specific targets for anti-relapse medication approaches. View Full-Text

Keywords: addiction; hypocretin; orexin; reinstatement; relapse addiction; hypocretin; orexin; reinstatement; relapse





Autor: Luyi Zhou, Wei-Lun Sun and Ronald E. See *

Fuente: http://mdpi.com/



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