Spectrophotometric Determination of Metoprolol Tartrate in Pharmaceutical Dosage Forms on Complex Formation with CuIIReportar como inadecuado




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Department of Chemistry, Faculty of Science and Arts, University of Kahramanmaraş Sütçü Imam, Campuse of Avsar, 46100, Kahramanmaras, Turkey





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Abstract A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate MPT, which is based on the complexation of drug with copperII CuII at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer’s law within the concentration range 8.5-70 mg-mL. Regression analysis of the calibration data showed a good correlation coefficient r = 0.998 with a limit of detection of 5.56 mg-mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copperII complex of MPT Cu2MPT2Cl2 have been reported. View Full-Text

Keywords: b-blockers; metoprolol; complexation; spectrophotometry b-blockers; metoprolol; complexation; spectrophotometry





Autor: Mustafa Cesme, Derya Tarinc and Aysegul Golcu *

Fuente: http://mdpi.com/



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