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1

Department of Rural Health NSW, University of Newcastle, Tamworth, NSW 2340, Australia

2

Tamworth Rural Referral Hospital, Tamworth, NSW 2340, Australia

3

Nutrition and Dietetics, University of Canberra, Bruce, ACT 2617, Australia

4

School of Health Sciences, University of Newcastle, Callaghan, NSW 2308, Australia

5

School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia

6

School of Medicine, Bond University, Robina, QLD 4226, Australia





*

Author to whom correspondence should be addressed.



Abstract The aims of this study were to: 1 determine whether replacement of cow’s milk protein with soy resolves Chronic Functional Constipation CFC; and 2 investigate the effects of cow’s milk β casein A1 and cow’s milk β casein A2 on CFC. Children diagnosed with CFC were recruited to one of two crossover trials: Trial 1 compared the effects of cow’s milk and soy milk; Trial 2 compared the effects of cow’s milk β casein A1 and cow’s milk β casein A2. Resolution of constipation was defined as greater than eight bowel motions during a two week intervention. Thirteen children 18 to 144 months participated in Trial 1 6 boys, 7 girls. Nine participants who completed the soy epoch all experienced resolution p < 0.05. Thirty-nine children 21 to 144 months participated in Trial 2 25 boys, 14 girls. Resolution of constipation was highest during the washout epoch, 81%; followed by cow’s milk β casein A2, 79%; and cow’s milk β casein A1, 57%; however, the proportions did not differ statistically. The results of Trial 1 demonstrate an association between CFC and cow’s milk consumption but Trial 2 failed to show an effect from type of casein. Some other component in cow’s milk common to both A1 and A2 milk may be causing a problem in these susceptible children. View Full-Text

Keywords: constipation; child; hypersensitivity; soy; casein constipation; child; hypersensitivity; soy; casein





Autor: Elesa T. Crowley 1,2,* , Lauren T. Williams 3,4, Tim K. Roberts 5, Richard H. Dunstan 5 and Peter D. Jones 6

Fuente: http://mdpi.com/



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