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Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA





Abstract Eggs are a major source of phospholipids PL in the Western diet. Dietary PL have emerged as a potential source of bioactive lipids that may have widespread effects on pathways related to inflammation, cholesterol metabolism, and high-density lipoprotein HDL function. Based on pre-clinical studies, egg phosphatidylcholine PC and sphingomyelin appear to regulate cholesterol absorption and inflammation. In clinical studies, egg PL intake is associated with beneficial changes in biomarkers related to HDL reverse cholesterol transport. Recently, egg PC was shown to be a substrate for the generation of trimethylamine N-oxide TMAO, a gut microbe-dependent metabolite associated with increased cardiovascular disease CVD risk. More research is warranted to examine potential serum TMAO responses with chronic egg ingestion and in different populations, such as diabetics. In this review, the recent basic science, clinical, and epidemiological findings examining egg PL intake and risk of CVD are summarized. View Full-Text

Keywords: atherosclerosis; cardiovascular disease; egg; HDL; phosphatidylcholine; phospholipids; sphingomyelin; TMAO atherosclerosis; cardiovascular disease; egg; HDL; phosphatidylcholine; phospholipids; sphingomyelin; TMAO





Autor: Christopher N. Blesso

Fuente: http://mdpi.com/



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