A Green Algae Mixture of Scenedesmus and Schroederiella Attenuates Obesity-Linked Metabolic Syndrome in RatsReportar como inadecuado




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1

Centre for Systems Biology, University of Southern Queensland, Toowoomba 4350, Australia

2

MACRO—the Centre for Macroalgal Resources & Biotechnology, College of Marine and Environmental Sciences, James Cook University, Townsville 4811, Australia

3

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia

4

School of Health and Wellbeing, University of Southern Queensland, Toowoomba 4350, Australia





*

Authors to whom correspondence should be addressed.



Abstract This study investigated the responses to a green algae mixture of Scenedesmus dimorphus and Schroederiella apiculata SC containing protein 46.1% of dry algae, insoluble fibre 19.6% of dry algae, minerals 3.7% of dry algae and omega-3 fatty acids 2.8% of dry algae as a dietary intervention in a high carbohydrate, high fat diet-induced metabolic syndrome model in four groups of male Wistar rats. Two groups were fed with a corn starch diet containing 68% carbohydrates as polysaccharides, while the other two groups were fed a diet high in simple carbohydrates fructose and sucrose in food, 25% fructose in drinking water, total 68% and fats saturated and trans fats from beef tallow, total 24%. High carbohydrate, high fat-fed rats showed visceral obesity with hypertension, insulin resistance, cardiovascular remodelling, and nonalcoholic fatty liver disease. SC supplementation 5% of food lowered total body and abdominal fat mass, increased lean mass, and attenuated hypertension, impaired glucose and insulin tolerance, endothelial dysfunction, infiltration of inflammatory cells into heart and liver, fibrosis, increased cardiac stiffness, and nonalcoholic fatty liver disease in the high carbohydrate, high fat diet-fed rats. This study suggests that the insoluble fibre or protein in SC helps reverse diet-induced metabolic syndrome. View Full-Text

Keywords: visceral obesity; metabolic symptoms; microalgae; insoluble fibre visceral obesity; metabolic symptoms; microalgae; insoluble fibre





Autor: Senthil Arun Kumar 1,* , Marie Magnusson 2, Leigh C. Ward 3, Nicholas A. Paul 2 and Lindsay Brown 4,*

Fuente: http://mdpi.com/



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