Soy Protein-Based Infant Formulas with Supplemental Fructooligosaccharides: Gastrointestinal Tolerance and Hydration Status in Newborn InfantsReportar como inadecuado




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Abbott Nutrition, Abbott Laboratories, Columbus, OH 43219, USA





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Abstract Unlike milk-based infant formulas, soy-based infant formulas containing supplemental fructooligosaccharides FOS have not been clinically evaluated. A randomized, double-blind, 28 day parallel feeding trial compared gastrointestinal GI tolerance and hydration in healthy term newborn infants fed either a commercialized soy formula with history of safe use containing sucrose as 20% of total carbohydrate, no supplemental short-chain FOS scFOS and no mixed carotenoids lutein, lycopene, beta-carotene as a control CF, n = 62 infants or one of two experimental soy-based formulas, EF1 n = 64 and EF2 n = 62 containing scFOS 2.5 g-L and mixed carotenoids. EF1 differed from EF2 by containing sucrose. Results indicated no significant study group differences p > 0.05 in study completion rates CF = 81, EF1 = 86, and EF2 = 87%, growth, mean rank stool consistency, stool frequency, formula intake, spit-up-vomit, and safety measures urine specific gravity, USG; hydration status and adverse events. Mean USGs for study groups were normal <1.03. The EF1 > CF group in percent yellow stools p < 0.01 at age 14 days. In conclusion, the study suggested that term infants fed soy-based formulas supplemented with scFOS and mixed carotenoids, with or without sucrose in the 1st 35 days of infancy demonstrated good tolerance and hydration comparable to the control soy-based formula with history of safe use. View Full-Text

Keywords: gastrointestinal tolerance; hydration; term infants; soy infant formulas; fructooligosaccharides; carotenoids gastrointestinal tolerance; hydration; term infants; soy infant formulas; fructooligosaccharides; carotenoids





Autor: John Lasekan * , Geraldine Baggs, Sonja Acosta and Amy Mackey

Fuente: http://mdpi.com/



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