Maternal Consumption of Non-Staple Food in the First Trimester and Risk of Neural Tube Defects in OffspringReportar como inadecuado




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1

Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 WenhuaXilu Road, Jinan 250012, Shandong, China

2

Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, Zhejiang, China





*

Author to whom correspondence should be addressed.



Abstract To study the associations between maternal consumption of non-staple food in the first trimester and risk of neural tube defects NTDs in offspring. Data collected from a hospital-based case-control study conducted between 2006 and 2008 in Shandong-Shanxi provinces including 459 mothers with NTDs-affected births and 459 mothers without NTDs-affected births. Logistic regression models were used to examine the associations between maternal consumption of non-staple food in the first trimester and risk of NTDs in offspring. The effects were evaluated by odds ratio OR and 95% confidence intervals 95% CIs with SAS9.1.3.software. Maternal consumption of milk, fresh fruits and nuts in the first trimester were protective factors for total NTDs. Compared with consumption frequency of ˂1 meal-week, the ORs for milk consumption frequency of 1–2, 3–6, ≥7 meals-week were 0.50 95% CI: 0.28–0.88, 0.56 0.32–0.99, and 0.59 0.38–0.90, respectively; the ORs for fresh fruits consumption frequency of 1–2, 3–6, ≥7 meals-week were 0.29 95% CI: 0.12–0.72, 0.22 0.09–0.53, and 0.32 0.14–0.71, respectively; the ORs for nuts consumption frequency of 1–2, 3–6, ≥7 meals-week were 0.60 95% CI: 0.38–0.94, 0.49 0.31–0.79, and 0.63 0.36–1.08, respectively. Different effects of above factors on NTDs were found for subtypes of anencephaly and spina bifida. Maternal non-staple food consumption of milk, fresh fruits and nuts in the first trimester was associated with reducing NTDs risk in offspring. View Full-Text

Keywords: case-control study; nutrition; neural tube defects case-control study; nutrition; neural tube defects





Autor: Meng Wang 1,2, Zhi-Ping Wang 1, Li-Jie Gao 1, Hui Yang 1 and Zhong-Tang Zhao 1,*

Fuente: http://mdpi.com/



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