Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive SubjectsReportar como inadecuado




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1

Unilever Research & Development Vlaardingen, Olivier van Noortlaan 120, Vlaardingen 3133 AT, The Netherlands

2

Academic Medical Center Amsterdam, Department of Vascular Medicine, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands



Current address: Menzis, Lawickse Allee 130, Wageningen 6709 DZ, The Netherlands.



Current address: Imagelabonline & Cardiovascular, Erichem 4117 GV, The Netherlands.

§

Current address: Red Pharm, Cold Meece, Swynnerton, Staffordshire ST15 0SP, UK.





*

Author to whom correspondence should be addressed.



Abstract Polyphenols in grape and wine have been suggested to contribute to the cardiovascular health benefits of the Mediterranean lifestyle. The reported effects of grape products on blood pressure BP remain, however, equivocal. In a double-blind placebo controlled crossover study, the effect of two grape extracts on BP and vascular function was assessed in 60 untreated, mildly hypertensive subjects after four weeks intervention. Both extracts grape-red wine and grape alone had high concentrations of anthocyanins and flavonols, but the grape alone was relatively poor in catechins and procyanidins. Parameters measured included ambulatory and office BP, flow-mediated vasodilation, arterial distensibility, platelet function and plasma lipoproteins. Results showed that 24-hour ambulatory systolic-diastolic BPs were significantly lower in the grape-wine extract intervention 135.9 ± 1.3-84.7 ± 0.8 mmHg; mean ± SEM compared to placebo 138.9 ± 1.3-86.6 ± 1.2 mmHg, predominantly during daytime. Plasma concentrations of the vasoconstrictor endothelin-1 decreased by 10%, but other measures of vascular function were not affected. Grape juice extract alone had no effect on BP or any measures of vascular function. Polyphenol-rich food products, and may be specifically catechins and procyanidins, may thus help sustain a healthy BP and contribute to the healthy Mediterranean lifestyle. View Full-Text

Keywords: red wine; grape; polyphenols; blood pressure; vascular function; catechins; procyanidins red wine; grape; polyphenols; blood pressure; vascular function; catechins; procyanidins





Autor: Richard Draijer 1,* , Young de Graaf 1, Marieke Slettenaar 1,†, Eric de Groot 2,‡ and Chris I. Wright 1,§

Fuente: http://mdpi.com/



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