Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 DiabetesReportar como inadecuado


Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes


Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China





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Abstract Renal tubular injury is a critical factor in the pathogenesis of diabetic nephropathy DN. Endoplasmic reticulum ER stress is involved in diabetic nephropathy. Tauroursodeoxycholic acid TUDCA is an effective inhibitor of ER stress. Here, we investigated the role of TUDCA in the progression of tubular injury in DN. For eight weeks, being treated with TUDCA at 250 mg-kg intraperitoneal injection i.p. twice a day, diabetic db-db mice had significantly reduced blood glucose, albuminuria and attenuated renal histopathology. These changes were associated with a significant decreased expression of ER stress markers. At the same time, diabetic db-db mice had more TUNEL-positive nuclei in the renal tubule, which were attenuated by TUDCA treatment, along with decreases in ER stress–associated apoptotic markers in the kidneys. In summary, the effect of TUDCA on tubular injury, in part, is associated with inhibition of ER stress in the kidneys of diabetic db-db mice. TUDCA shows potential as a therapeutic target for the prevention and treatment of DN. View Full-Text

Keywords: diabetic nephropathy; endoplasmic reticulum stress; apoptosis; tauroursodeoxycholic acid diabetic nephropathy; endoplasmic reticulum stress; apoptosis; tauroursodeoxycholic acid





Autor: Jing Zhang, Ying Fan, Chuchu Zeng, Li He and Niansong Wang *

Fuente: http://mdpi.com/



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