Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley RatsReportar como inadecuado


Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats


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Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada





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Abstract Higher intakes of polyunsaturated fatty acids PUFA are associated with benefits at several skeletal sites in postmenopausal women and in rodent models, but the effect of PUFA-containing oils on tooth-supporting alveolar bone of the mandible has not been studied. Moreover, direct comparison of the effect of flaxseed oil a source of alpha-linolenic acid ALA and menhaden oil a source of eicosapentaenoic acid EPA and docosahexaenoic acid DHA is unknown. One-month old female Sprague-Dawley rats n = 48 were randomized to and fed a diet containing flaxseed oil or menhaden oil from one to six months of age. At three months of age, rats were randomized to receive SHAM or ovariectomy OVX surgery n = 12-diet. The inter-radicular septum below the first molar of the mandible was imaged at 6 months of age study endpoint using micro-computed tomography μCT at a resolution of 9 μm. As expected, OVX significantly reduced percent bone volume BV-TV, connectivity density Conn. D., trabecular number Tb. N., and increased trabecular separation Tb. Sp. compared to SHAM rats p < 0.001. However, post hoc analysis revealed these differences were present in rats fed menhaden oil but not those fed flaxseed oil. These results suggest that providing flaxseed oil, possibly through its high ALA content, provides protection against the OVX-induced alveolar bone loss in rats. View Full-Text

Keywords: alveolar bone; mandible; micro-computed tomography; omega-3 fatty aids; alpha-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; ovariectomy; flaxseed oil; fish oil alveolar bone; mandible; micro-computed tomography; omega-3 fatty aids; alpha-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; ovariectomy; flaxseed oil; fish oil





Autor: Amanda B. Longo and Wendy E. Ward *

Fuente: http://mdpi.com/



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