The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal CancerReportar como inadecuado


The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer


The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Bromatology, Hygiene, Nutrition, University of Medicine and Pharmacy -Iuliu Hatieganu-, Marinescu Street 23, Cluj-Napoca 400337, Romania

2

Department of Pharmaceutical Biochemistry and Clinical Laboratory, University of Medicine and Pharmacy -Iuliu Hatieganu-, Louis Pasteur Street 6, Cluj-Napoca 400349, Romania

3

Department of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute -Prof. Dr. Ion Chiricuta-, Republicii Street 34-36, Cluj-Napoca 400015, Romania

4

Department of Surgical and Gynecological Oncology, University of Medicine and Pharmacy -Iuliu Hatieganu-, Republicii Street 34-36, Cluj-Napoca 400015, Romania

5

Department of Surgery, The Oncology Institute -Prof. Dr. Ion Chiricuta-, Republicii Street 34-36, Cluj-Napoca 400015, Romania





*

Author to whom correspondence should be addressed.



Abstract Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs miRNAs as key players in cancer-related pathways in the context of dietary modulation. MicroRNAs are involved in most biological processes related to tumor development and progression; therefore, it is of great interest to understand the underlying mechanisms by which dietary patterns and components influence the expression of these powerful molecules in colorectal cancer. In this review, we discuss relevant dietary patterns in terms of miRNAs modulation in colorectal cancer, as well as bioactive dietary components able to modify gene expression through changes in miRNA expression. Furthermore, we emphasize on protective components such as resveratrol, curcumin, quercetin, α-mangostin, omega-3 fatty acids, vitamin D and dietary fiber, with a focus on the molecular mechanisms in the context of prevention and even treatment. In addition, several bioactive dietary components that have the ability to re-sensitize treatment resistant cells are described. View Full-Text

Keywords: colorectal cancer; microRNA; diet; bioactive dietary components colorectal cancer; microRNA; diet; bioactive dietary components





Autor: Laura I. Gavrilas 1, Corina Ionescu 2, Oana Tudoran 3, Cosmin Lisencu 4,5, Ovidiu Balacescu 3,* and Doina Miere 1

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados