A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-AnalysisReportar como inadecuado


A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis


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1

Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06123, Italy

2

Department of Experimental Medicine, University of Perugia, Perugia 06123, Italy

3

Department of Economics, University of Perugia, Perugia 06123, Italy





*

Author to whom correspondence should be addressed.



Abstract Dietary patterns were recently applied to examine the relationship between eating habits and prostate cancer PC risk. While the associations between PC risk with the glycemic index and Mediterranean score have been reviewed, no meta-analysis is currently available on dietary patterns defined by -a posteriori- methods. A literature search was carried out PubMed, Web of Science to identify studies reporting the relationship between dietary patterns and PC risk. Relevant dietary patterns were selected and the risks estimated were calculated by a random-effect model. Multivariable-adjusted odds ratios ORs, for a first-percentile increase in dietary pattern score, were combined by a dose-response meta-analysis. Twelve observational studies were included in the meta-analysis which identified a -Healthy pattern- and a -Western pattern-. The Healthy pattern was not related to PC risk OR = 0.96; 95% confidence interval CI: 0.88–1.04 while the Western pattern significantly increased it OR = 1.34; 95% CI: 1.08–1.65. In addition, the -Carbohydrate pattern-, which was analyzed in four articles, was positively associated with a higher PC risk OR = 1.64; 95% CI: 1.35–2.00. A significant linear trend between the Western p = 0.011 pattern, the Carbohydrate p = 0.005 pattern, and the increment of PC risk was observed. The small number of studies included in the meta-analysis suggests that further investigation is necessary to support these findings. View Full-Text

Keywords: dietary pattern; prostate cancer; systematic review; meta-analysis dietary pattern; prostate cancer; systematic review; meta-analysis





Autor: Roberto Fabiani 1,* , Liliana Minelli 2, Gaia Bertarelli 3 and Silvia Bacci 3

Fuente: http://mdpi.com/



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