Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer ImagingReportar como inadecuado


Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging


Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Pharmaceutics, School of Pharmaceutical Science, Shandong University, Ji’nan 250012, China

2

Department of Radiology Medicine, Affiliated Qilu Hospital, Shandong University, Ji’nan 250012, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Academic Editor: Thomas Nann

Abstract Molecular imaging is essential to increase the sensitivity and selectivity of cancer diagnosis especially at the early stage of tumors. Recently, polyionic nanocomplexes PICs, which are composed of polyanions and opposite polycations, have been demonstrated to be a promising strategy for biomedical applications. In this work, chitosan-hyaluronic acid nanoparticles GCHN were developed to deliver Gd-DTPA as MRI contrast agents for tumor diagnosis. The Gd-labeled conjugates CS-DTPA-Gd were successfully synthesized by carbodiimide reaction, and then GCHN were prepared by ionic gelation using the obtained CS-DTPA-Gd and hyaluronic acid. The morphology of GCHN was spherical or ellipsoidal, which is observed by transmission electronic microscopy TEM. The mean particle size and zeta potential of GCHN were 213.8 ± 2.6 nm and 19.92 ± 1.69 mV, respectively. The significant enhancement of signal intensity induced by GCHN was observed both in vitro and in vivo. Also, compared with Magnevist, GCHN was witnessed for a prolonged imaging time in the B16 tumor-bearing mice model. Furthermore, GCHN were verified as below toxic both in vitro and in vivo. These results indicated that GCHN could potentially be an alternative to current MRI contrast agents for tumor diagnosis. View Full-Text

Keywords: tumor imaging; magnetic resonance imaging; hyaluronic acid; chitosan nanoparticles; Gd-DTPA tumor imaging; magnetic resonance imaging; hyaluronic acid; chitosan nanoparticles; Gd-DTPA





Autor: Li Zhang 1,†, Tingxian Liu 1,†, Yanan Xiao 1, Dexin Yu 2 and Na Zhang 1,*

Fuente: http://mdpi.com/



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