Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth StimulatorsReportar como inadecuado


Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators


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1

Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS 7509, Centre de Neurochimie, Université Louis Pasteur, 5, rue Blaise Pascal, 67084 Strasbourg cedex, France

2

Laboratoire de Neurophysiologie Cellulaire et Integrée, UMR CNRS 7519, Université Louis Pasteur, Strasbourg, France





*

Author to whom correspondence should be addressed.



Abstract Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth. View Full-Text

Keywords: cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis





Autor: Bang Luu 1,* , José-Luis González De Aguilar 1,2 and Céline Girlanda-Junges 1

Fuente: http://mdpi.com/



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