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1

Natural Drugs Department, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic

2

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic





*

Author to whom correspondence should be addressed.



Abstract Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decoratative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid-liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substantaces. We identified and quantified acteoside 1 and isoacteoside 2 in the EtOAc and n-BuOH extracts; mimulone 3 and diplacone 4 in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals. View Full-Text

Keywords: Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics Paulownia tomentosa; antioxidant; DPPH; antiperoxynitrite; phenolics





Autor: Karel Smejkal 1,* , Pavla Holubova 1, Ales Zima 1, Jan Muselik 2 and Margita Dvorska 1

Fuente: http://mdpi.com/



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