The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated MiceReportar como inadecuado


The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice


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1

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P. R. China

2

School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P. R. China





*

Author to whom correspondence should be addressed.



Abstract The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg-kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2-Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy. View Full-Text

Keywords: Daidzein; apoptosis; caspase 3; bcl-2; bax Daidzein; apoptosis; caspase 3; bcl-2; bax





Autor: Zhen Mao 1, Yuan-lin Zheng 1,* , Yan-qiu Zhang 1, Bao-ping Han 1, Xiao-wan Zhu 1, Qing Chang 1 and Xiang-bin Hu 1

Fuente: http://mdpi.com/



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