Antibacterial Thymol Derivatives Isolated from Centipeda minimaReportar como inadecuado


Antibacterial Thymol Derivatives Isolated from Centipeda minima


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1

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China

2

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P. R. China

3

Department of Microbiology and Immunology, Kunming Medical College, Kunming 650031, P. R. China

4

College of Bioengineering, Southwest Jiaotong University, Chengdu 610031, P. R. China





*

Author to whom correspondence should be addressed.



Abstract Two new monoterpenoids, 8,10-dihydroxy-92-methylbutyryloxythymol 1 and 10-hydroxy-8,9-dioxyisopropylidene-thymol 2, together with five known thymol derivatives: 8,9,10-trihydroxythymol 3, thymol-β-glucopyranoside 4, 9-hydroxythymol 5, 8,10-dihydroxy-9-isobutyryloxythymol 6, and 8-hydroxy-9,10-diisobutyryloxythymol 7, were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature. The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method. View Full-Text

Keywords: Centipeda minima; Compositae; thymol derivatives; antibacterial activity Centipeda minima; Compositae; thymol derivatives; antibacterial activity





Autor: Hengxing Liang 1, Fukai Bao 3, Xiaoping Dong 2, Rui Tan 4, Caijun Zhang 3, Qing Lu 1 and Yongxian Cheng 1,*

Fuente: http://mdpi.com/



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