Two Step Synthesis of a Non-symmetric Acetylcholinesterase ReactivatorReportar como inadecuado




Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

2

Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic

3

Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

4

Department of Food Technology, Mendel University of Agriculture and Forestry Brno, Zemedelska 1, 613 00 Brno, Czech Republic





*

Author to whom correspondence should be addressed.



Abstract The newly developed and very promising acetylcholinesterase reactivator E-1- 2-hydroxyiminomethylpyridinium-4-4-hydroxyiminomethylpyridinium-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate E-1-4-bromobut-2-enyl-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested. View Full-Text

Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents





Autor: Kamil Musilek 1, Kamil Kuca 1,* , Vlastimil Dohnal 1, Daniel Jun 1, Jan Marek 2 and Vit Koleckar 3

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados