Activities of Ten Essential Oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 Cancer CellsReportar como inadecuado




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1

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China

2

Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China

3

Chinese Medicine Department, The Second Hospital of Harbin Medical University, Harbin 150086, China

4

Department of Pharmaceutical Biology, Institute of Pharmacy, University of Mainz, 55099 Mainz, Germany



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Ten essential oils, namely, mint Mentha spicata L.,Lamiaceae, ginger Zingiber officinaleRosc.,Zingiberaceae, lemon Citrus limon Burm.f.,Rutaceae, grapefruit Citrus paradisi Macf., Rutaceae, jasmine Jasminum grandiflora L.,Oleaceae, lavender Mill.,Lamiaceae, chamomile Matricaria chamomilla L., Compositae, thyme Thymus vulgaris L., Lamiaceae, rose Rosa damascena Mill.,Rosaceae and cinnamon Cinnamomum zeylanicumN. Lauraceae were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 ± 1.2 mm, 33.5 ± 1.5 mm and 16.5 ± 0.7 mm, and minimal inhibitory concentrations of 0.016% v-v, 0.016% v-v and 0.031% v-v, respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% v-v, and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% IC50 values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% v-v, 0.011% v-v and 0.030% v-v, respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell PC-3 was significantly stronger than on human lung carcinoma A549 and human breast cancer MCF-7 cell lines.

Keywords: essential oils; activities; Propionibacterium acnes; cytotoxicity; cancer cell lines essential oils; activities; Propionibacterium acnes; cytotoxicity; cancer cell lines





Autor: Yuangang Zu 1,2,, Huimin Yu 3,, Lu Liang 1,2, Yujie Fu 1,2,* , Thomas Efferth 4, Xia Liu 1,2 and Nan Wu 1,2

Fuente: http://mdpi.com/



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