Antifungal Effect of -Pinoresinol Isolated from Sambucus williamsiiReportar como inadecuado




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1

School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu 702-701, Korea

2

College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Korea





*

Author to whom correspondence should be addressed.



Abstract In this study, we investigated the antifungal activity and mechanism of action of +-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. +-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of +-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene DPH indicated that the +-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle GUV experiments. Therefore, the present study indicates that +-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

Keywords: +-pinoresinol; lignan; antifungal compound; membrane-active mechanism; Sambucus williamsii HANCE +-pinoresinol; lignan; antifungal compound; membrane-active mechanism; Sambucus williamsii HANCE





Autor: Bomi Hwang 1, Juneyoung Lee 1, Qing-He Liu 2, Eun-Rhan Woo 2 and Dong Gun Lee 1,*

Fuente: http://mdpi.com/



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