The Reaction of Cyanoacetylhydrazine with ω-Bromo4-methylacetophenone: Synthesis of Heterocyclic Derivatives with Antitumor ActivityReportar como inadecuado




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1

Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt

2

Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt

3

National Organization for Drug Control & Research NODCAR, P.O. 29, Cairo, Egypt





*

Author to whom correspondence should be addressed.



Abstract New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma MCF-7, non-small cell lung cancer NCI-H460 and CNS cancer SF-268 were recorded. Most of the synthesized compounds showed high inhibitory effects.

Keywords: hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor





Autor: Rafat M. Mohareb 1,2,* and Abeer A. Mohamed 3

Fuente: http://mdpi.com/



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