Synthesis and Effect on Human HepG2 Cells of 1,2-bis- 2-MethylallyldisulfaneReportar como inadecuado




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1

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China

2

Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China





*

Author to whom correspondence should be addressed.



Abstract 1,2-bis2-methylallyldisulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis2-methylallyldisulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

Keywords: 1,2-bis2-methylallyldisulfane; identification; apoptosis 1,2-bis2-methylallyldisulfane; identification; apoptosis





Autor: Chunxiao Ji 1,* , Fenglian Ren 1, Jun Dai 1 and Ming Xu 2

Fuente: http://mdpi.com/



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