Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic AcidReportar como inadecuado




Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

College of Oriental Medicine, Department of Pathology, Kyungwon University, Seongnam 461-701, Korea





*

Author to whom correspondence should be addressed.



Abstract Myristicin 1-allyl-5-methoxy-3,4-methylenedioxybenzene is an active aromatic compound found in nutmeg the seed of Myristica fragrans, carrot, basil, cinnamon, and parsley. Myristicin has been known to have anti-cholinergic, antibacterial, and hepatoprotective effects, however, the effects of myristicin on virus-stimulated macrophages are not fully reported. In this study, the anti-inflammatory effect of myristicin on double-stranded RNA dsRNA-stimulated macrophages was examined. Myristicin did not reduce the cell viability of RAW 264.7 mouse macrophages at concentrations of up to 50 µM. Myristicin significantly inhibited the production of calcium, nitric oxide NO, interleukin IL-6, IL-10, interferon inducible protein-10, monocyte chemotactic protein MCP-1, MCP-3, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein MIP-1α, MIP-1β, and leukemia inhibitory factor in dsRNA polyinosinic-polycytidylic acid-induced RAW 264.7 cells P 0.05. In conclusion, myristicin has anti-inflammatory properties related with its inhibition of NO, cytokines, chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway.

Keywords: myristicin; dsRNA; inflammation; macrophages; cytokine myristicin; dsRNA; inflammation; macrophages; cytokine





Autor: Ji Young Lee and Wansu Park *

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados