A Practical Approach to New 5Z 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one DerivativesReportar como inadecuado




A Practical Approach to New 5Z 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Chemical Engineering & Molecules for Life Sciences Group, Université de Rennes 1, Sciences Chimiques de Rennes SCR, UMR CNRS 6226, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France

2

Protein Phosphorylation and Human Disease Group, Station Biologique CNRS, Place G. Tessier, BP 74, 29682 Roscoff, France





*

Author to whom correspondence should be addressed.



Abstract A practical protocol for the preparation of 5Z-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.

Keywords: 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation





Autor: Khadidja Bourahla 1, Ludovic Paquin 1, Olivier Lozach 2, Laurent Meijer 2, François Carreaux 1 and Jean Pierre Bazureau 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados