Antioxidant, Anti-Lipoxygenase and Cytotoxic Activity of Leptadenia pyrotechnica Forssk. Decne Polyphenolic ConstituentsReportar como inadecuado




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1

Department of Chemistry, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE

2

National Organization of Drug Control and Research, 6 Abu Hazem St., Giza, Egypt

3

Department of Biology, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE

4

Department of Biochemistry, Faculty of Medicine and Health Sciences, U.A.E. University, Al-Ain, P.O. Box 17666, UAE





*

Author to whom correspondence should be addressed.



Abstract Leptadenia pyrotechnica Forssk is a traditional medicinal herb used for treatment of inflammatory diseases and cancer. In this research, the aqueous ethanolic crude extract of Leptadenia pyrotechnica aerial parts, along with its ethyl acetate, n-butanol and water partitioning fractions were evaluated for their antioxidant capacity, polyphenolic content, anti-inflammatory and anti-cancer properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and β-carotene bleaching assays.The ethyl acetate fraction exhibited the highest polyphenolic content 252.27 mg gallic acid-g and the best antioxidant activity 1.2, 0.57, 0.45 mmol ascorbic acid equivalent-g in the FRAP, ABTS and DPPH assays, respectively. Furthermore, the same extract showed appreciable anti-inflammatory via lipoxygenase LOX inhibitory activity IC50 = 1.41 µg-mL. Moreover, the ethyl acetate fraction also showed the strongest cytotoxic effect IC50 = 43.16 µg-mL against MCF-7 human breast cancer cell line. These results suggest that this plant may be considered an interesting source of compounds with antioxidant, anti-inflammatory and anti-cancer properties for therapeutic, nutraceutical and functional food applications.

Keywords: Leptadenia pyrotechnica; total phenol; antioxidant; anti-inflammatory; cytotoxicity Leptadenia pyrotechnica; total phenol; antioxidant; anti-inflammatory; cytotoxicity





Autor: Mohammad A. Khasawneh 1,* , Hanan M. Elwy 1,2, Alaaeldin A. Hamza 3, Nael M. Fawzi 3 and Ahmed H. Hassan 4

Fuente: http://mdpi.com/



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