Synthesis of No-Carrier-Added 4-18FFluorophenol from 4-Benzyloxyphenyl-2-thienyliodonium BromideReportar como inadecuado




Synthesis of No-Carrier-Added 4-18FFluorophenol from 4-Benzyloxyphenyl-2-thienyliodonium Bromide - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany



Current address: Institute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, 55128 Mainz, Germany.





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Abstract 4-18FFluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-18Ffluorophenoxy moiety. In order to prepare 4-18Ffluorophenol in no-carrier-added n.c.a. form only a nucleophilic labelling method starting from 18Ffluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-2-thienyliodonium bromide and 18Ffluoride with subsequent deprotection is described, yielding n.c.a. 18Ffluorophenol in 34 to 36% radiochemical yield.

Keywords: fluorine-18; 4-18Ffluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography fluorine-18; 4-18Ffluorophenol; diaryl iodonium salts; radiosynthesis; positron emission tomography





Autor: Tobias L. Ross †, Johannes Ermert * and Heinz H. Coenen

Fuente: http://mdpi.com/



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