Synthesis and Structural Characterization of 1-2-5-Nitro-1H-indol-2-ylphenylmethylpyridinium ChlorideReportar como inadecuado




Synthesis and Structural Characterization of 1-2-5-Nitro-1H-indol-2-ylphenylmethylpyridinium Chloride - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia

2

Department of Chemistry, Srinakharinwirot University, Bangkok 10110, Thailand

3

School of Biomedical, Biomolecular and Chemical Sciences, Chemistry M313, The University of Western Australia, Crawley, W.A. 6009, Australia





*

Author to whom correspondence should be addressed.



Abstract In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1H-indole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-2-5-nitro-1H-indol-2-ylphenylmethylpyridinium chloride 2 was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21-c with the following unit cell dimensions: a 10.2743 Å, b 13.1014 Å, c 13.4394 Å, b 107.7027°, V 1723.29 Å3, Z f.u. = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the intramolecular disposition of the pyridinium plane over the indole heterocyclic residue interplanar dihedral angle 17.914°.

Keywords: indole; pyridinium salt; X-ray crystal structure indole; pyridinium salt; X-ray crystal structure





Autor: John B. Bremner 1,* , Siritron Samosorn 2, Brian W. Skelton 3 and Allan H. White 3

Fuente: http://mdpi.com/



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