The Dual Action of Epigallocatechin Gallate EGCG, the Main Constituent of Green Tea, against the Deleterious Effects of Visible Light and Singlet Oxygen-Generating Conditions as Seen in Yeast CellsReportar como inadecuado




The Dual Action of Epigallocatechin Gallate EGCG, the Main Constituent of Green Tea, against the Deleterious Effects of Visible Light and Singlet Oxygen-Generating Conditions as Seen in Yeast Cells - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Postgraduate Department of Biochemistry, University of Medicine & Pharmacy -Carol Davila-, Sos. Fundeni 258, Bucharest, Romania

2

Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Sos. Panduri 90-92, Bucharest, Romania



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Green tea extracts GTEs as well as their main component, the polyphenol epigallocatechin gallate EGCG, are known for their versatile antioxidant, antimicrobial, antitumoral or anti-inflammatory effects. In spite of the huge beneficial action, there is increasing evidence that under certain conditions green tea and its components can be detrimental to living organisms. Using Saccharomyces cerevisiae strains with various defects in the response to oxidative stress, we found that GTEs or EGCG act in synergy with visible light, exhibiting either deleterious or protective effects depending on the solvent employed. Similar synergistic effects could be observed under singlet oxygen-generating conditions, such as light exposure in the presence of photosensitizers or UV-A irradiation, therefore solvent variance may represent a powerful tool to modulate the preparation of green tea extracts, depending on the intended target.

Keywords: green tea; epigallocatechin gallate; Saccharomyces cerevisiae; visible light; singlet oxygen; UV-A green tea; epigallocatechin gallate; Saccharomyces cerevisiae; visible light; singlet oxygen; UV-A





Autor: Radu Mitrica 1,†, Ioana Dumitru 2,†, Lavinia L. Ruta 2, Augustin M. Ofiteru 2 and Ileana C. Farcasanu 2,*

Fuente: http://mdpi.com/



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