Platelet-Activating Factor PAF Antagonistic Activity of a New Biflavonoid from Garcinia nervosa var. pubescens KingReportar como inadecuado




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1

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

2

Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia





*

Author to whom correspondence should be addressed.



Abstract The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor PAF receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4,II-4-hexahydroxy-I-3,II-8-flavonylflavanonol together with two known flavonoids, 6-methyl-4-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC50 values of 28.0 and 20.4 µM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.

Keywords: Garcinia nervosa var. pubescens; biflavonoid; platelet-activating factor PAF antagonists; platelets Garcinia nervosa var. pubescens; biflavonoid; platelet-activating factor PAF antagonists; platelets





Autor: Juriyati Jalil 1,* , Ibrahim Jantan 1, Azura Abdul Ghani 1 and Shahnaz Murad 2

Fuente: http://mdpi.com/



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