Synthesis of Highly Substituted Oxazoles through IodineIII-Mediated Reactions of Ketones with NitrilesReportar como inadecuado




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Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan



Current address: Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo 184-8588, Japan





*

Authors to whom correspondence should be addressed.



Abstract In the presence of trifluoromethanesulfonic acid TfOH or bistrifluoromethane-sulfonylimide Tf2NH, iodosobenzene PhI=O efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.

Keywords: single-step synthesis; iodineIII; oxazole; ketone; nitrile single-step synthesis; iodineIII; oxazole; ketone; nitrile





Autor: Akio Saito †,* , Nao Hyodo and Yuji Hanzawa *

Fuente: http://mdpi.com/



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