In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana PlantsReportar como inadecuado




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1

Institute for Research in Molecular Medicine INFORMM, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia

2

School of Biological Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia

3

Dental Research & Training Unit and Oral Cancer Research and Coordinating Centre OCRCC, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia





*

Author to whom correspondence should be addressed.



Abstract Lantadenes are pentacyclic triterpenoids present in the leaves of the plant Lantana camara. In the present study, in vitro antioxidant activity and free radical scavenging capacity of lantadene A was evaluated using established in vitro models such as ferric reducing antioxidant power FRAP, 2,2-diphenyl-1-picryl-hydrazyl DPPH•, hydroxyl radical OH•, nitric oxide radical NO•, superoxide anion scavenging activities and ferrous ion chelating assay. Interestingly, lantadene A showed considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner when compared with the standard antioxidant in nitric oxide scavenging, superoxide anion radical scavenging and ferrous ion chelating assay. These findings show that the lantadene A possesses antioxidant activity with different mechanism of actions towards the different free radicals tested. Since lantadene A is a very popular drug in modern medicine, it is a promising candidate for use as an antioxidant and hepatoprotective agent.

Keywords: antioxidant activity; free radical; lantadene A; triterpenes antioxidant activity; free radical; lantadene A; triterpenes





Autor: Chong Grace-Lynn 1, Ibrahim Darah 2, Yeng Chen 3, Lachimanan Yoga Latha 1, Subramanion L. Jothy 1 and Sreenivasan Sasidharan 1,*

Fuente: http://mdpi.com/



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