Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s DiseaseReportar como inadecuado




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Department of Biotechnology, Konkuk University, Chungju 380-701, Korea





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Abstract Parkinson’s disease PD is a complex multifactorial disease marked by extensive neuropathology in the brain with selective yet prominent and progressive loss of mid-brain dopaminergic neurons. The etiological factors involved in the development of PD are still elusive, but oxidative stress arising when reactive oxygen species ROS exceed amounts required for normal redox signaling is considered one of the major factors. ROS cause oxidative damage to proteins, lipids, and DNA and are one of the most prominent factors related to neurodegeneration. Pre-clinical and clinical studies clearly demonstrate the effectiveness of oxidative stress in the pathogenesis of PD. Therefore, regulation of redox signaling and inhibiting excess ROS would contribute greatly not only to extend longevity but also to ameliorate the progression of dopaminergic cell death seen in patients with PD. Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress. Here, we summarize the recent knowledge concerning promising herbs that have shown significant beneficial effects based on regulation of redox status and ROS inhibition in toxin-induced PD models. View Full-Text

Keywords: Parkinson’s disease; oxidative stress; redox signaling; antioxidant herbs; reactive oxygen species; 6-hydroxydopamine; substantia nigra Parkinson’s disease; oxidative stress; redox signaling; antioxidant herbs; reactive oxygen species; 6-hydroxydopamine; substantia nigra





Autor: Sushruta Koppula, Hemant Kumar, Sandeep Vasant More, Hyung-Woo Lim, Soon-Min Hong and Dong-Kug Choi *

Fuente: http://mdpi.com/



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