Silica Gel-Mediated Organic Reactions under Organic Solvent-Free ConditionsReportar como inadecuado




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Institute for Materials Chemistry and Engineering IMCE, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan





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Abstract Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as 1 the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, 2 one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and 3 the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.

Keywords: aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium





Autor: Satoaki Onitsuka, Yong Zhi Jin, Ajam C. Shaikh, Hiroshi Furuno and Junji Inanaga *

Fuente: http://mdpi.com/



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