Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass SpectrometryReportar como inadecuado




Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass Spectrometry - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

2

Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China

3

Hunan University of Chinese Medicine, Changsha 410208, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract As a traditional Miao-nationality medicinal plant, Polygonum capitatum has been used in clinical practice for several thousand years. Its prescriptions, including three dosage forms: granules, capsule and tablet are known by the brand name Relinqing® and have played an indispensable role in the treatment of urinary system infection, pyelonephritis and kidney stones. However, no study about the comprehensive quality evaluation of Relinqing® has been reported. In the present paper, a method for the simultaneous determination of nine major compounds in three dosage forms of Relinqing® using HPLC coupled with triple quadrupole mass spectrometry HPLC-QQQ MS was established to comprehensively evaluate their quality. The nine compounds, including four phenolic acids, four flavonoids and a lignin, were analyzed with acceptable linear regression relationship r2, 0.9923–0.9992, precision RSD, 1.25%–2.78%, repeatability RSD, 2.05%%–3.47%, stability RSD, 1.84%–3.72% and recovery 93.60%–108.54%, RSD ≤ 3.67%. The present study fills the gap in the multivariate quality control of Relinqing® and provides a valuable reference for quality standards and dosage reforming of this traditional Chinese medicine. View Full-Text

Keywords: Polygonum capitatum; Relinqing®; HPLC-QQQ MS; quality control Polygonum capitatum; Relinqing®; HPLC-QQQ MS; quality control





Autor: Kai-Xia Zhang 1,2,†, Yue-Sheng Wang 1,3,†, Wen-Guang Jing 1, Jun Zhang 1 and An Liu 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados