The Effect of Butanolides from Cinnamomum tenuifolium on Platelet AggregationReportar como inadecuado




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1

Department of Physical Therapy, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan

2

Department of Health Beauty, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan

3

Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, Ta-Liao District, Kaohsiung 83102, Taiwan





*

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Abstract This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate ADP-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide 1 and 2 μg-μL and tenuifolide B 1, 2 and 4 μg-μL did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide 4 μg-μL resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses. View Full-Text

Keywords: Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation Cinnamomum tenuifolium; isotenuifolide; tenuifolide B; platelet aggregation





Autor: Huei-Ping Dong 1,* , Hui-Ming Wu 2, Sheue-Jiun Chen 2 and Chung-Yi Chen 3,*

Fuente: http://mdpi.com/



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