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1

Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia

2

Department of Chemistry, Alvas Institute of Engineering & Technology, Mijar, Moodbidri 574225, India

3

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia





*

Author to whom correspondence should be addressed.



Abstract A series of six novel heterocyclic chalcone analogues 4a–f has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC50 values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent. View Full-Text

Keywords: heterocyclic; radical scavenging; reducing; substituent; overlay heterocyclic; radical scavenging; reducing; substituent; overlay





Autor: C. S. Chidan Kumar 1,2, Wan-Sin Loh 1, Chin Wei Ooi 1, Ching Kheng Quah 1 and Hoong-Kun Fun 1,3,*

Fuente: http://mdpi.com/



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