Lepidotrichilins A and B, New Protolimonoids with Cytotoxic Activity from Trichilia Lepidota MeliaceaeReportar como inadecuado




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1

Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego 2000, 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil

2

Laboratório de Biologia do Reconhecer, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego 2000, 28013-602, Campos dos Goytacazes, Rio de Janeiro, Brazil

3

Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 60021-970, Fortaleza, Ceará, Brazil





*

Author to whom correspondence should be addressed.



Abstract Two novel protolimonoids, named lepidotrichilins A 1 and B 2, four known protolimonoids, 21,23-epoxy-7α-21α-dihydroxyapotirucalla-14,24-dien-3-one 3, 21,23-epoxy-7α-21β-dihydroxyapotiru-calla-14,24-dien-3-one 4, dysorone D 5, deoxy-flindissone 6, and the two steroids β-sitosterol 7 and stigmasterol 8 were identified in leaves of Trichilia lepidota subsp. schumanniana Harms T.D. Pennington. From wood the coumarin scopoletin 9 was isolated. The structures were established by NMR 1D 1H and 13C-NMR and 2D 1H-1H COSY, HMQC and HMBC, mass spectroscopy and infrared IR spectral data. The hexane and methanol extracts of the leaves, the protolimonoids lepidotrichilins A 1 and B 2 IC50 42.7 µg mL−1 and the protolimonoid deoxy-flindissone 6; IC50 9.3 µgmL−1 exhibited significant cytotoxic activity against the MOLT-4 and U937 leukemic cell lines. View Full-Text

Keywords: Trichilia lepidota; Meliaceae; protolimonoids; spectral data; leukemic cell lines Trichilia lepidota; Meliaceae; protolimonoids; spectral data; leukemic cell lines





Autor: Wagner da S. Terra 1, Ivo J. C. Vieira 1,* , Raimundo Braz-Filho 1, William R. de Freitas 2, Milton M. Kanashiro 2 and Maria Conceiço M. Torres 3

Fuente: http://mdpi.com/



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