In Vitro Anti-Candida Activity of Certain New 3-1H-Imidazol-1-ylpropan-1-one Oxime EstersReportar como inadecuado




In Vitro Anti-Candida Activity of Certain New 3-1H-Imidazol-1-ylpropan-1-one Oxime Esters - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

2

Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza 12622, Egypt

3

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

4

Department of Microbiology, Faculty of Pharmacy, Alexandria University, Alexandria 21500, Egypt





*

Author to whom correspondence should be addressed.



Abstract Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely E-3-1H-imidazol-1-yl-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol-mL being more potent than both fluconazole MIC > 1.6325 µmol-mL and miconazole MIC value = 0.0188 µmol-mL as a new anti-Candida albicans agent. View Full-Text

Keywords: synthesis; Mannich reaction; azoles; oxime esters; anti-Candida synthesis; Mannich reaction; azoles; oxime esters; anti-Candida





Autor: Mohamed I. Attia 1,2,* , Azza S. Zakaria 3,4, Maha S. Almutairi 1 and Soraya W. Ghoneim 1

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados