Mechanical, Rheological and Release Behaviors of a Poloxamer 407- Poloxamer 188-Carbopol 940 Thermosensitive Composite HydrogelReportar como inadecuado




Mechanical, Rheological and Release Behaviors of a Poloxamer 407- Poloxamer 188-Carbopol 940 Thermosensitive Composite Hydrogel - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, Guangdong, China





*

Author to whom correspondence should be addressed.



Abstract The aims of this study were to prepare a thermosensitive composite hydrogel TCH by mixing 24% w-v poloxamer 407 P407, 16% w-v poloxamer 188 P188 and 0.1% w-v carbopol 940 C940, and to determine the effect of natural borneol- 2-hydroxypropyl-β-cyclodextrin NB-HP-β-CD inclusion complex on the phase transition temperature, mechanical, rheological properties, and release behaviors of the TCH using the tube inversion method, a texture analyzer, a rheometer, and in vitro release , respectively. The results showed that as the concentration of NB-HP-β-CD increased, the phase transition temperature of the TCH was increased from 37.26 to 38.34 °C and the mechanical properties of the TCH showed that the hardness, cohesiveness, strength, and adhesiveness were increased from 0.025 to 0.064 kg, 0.022 to 0.064 kg, 0.110 to 0.307 kg and 0.036 to 0.105 kg, respectively, but the rheological properties of the TCH showed that G′, G′′ and η were decreased from 7,760 to 157.50 Pa, 1,274 to 36.28 Pa and 1,252 to 25.37 Pas, respectively. The in vitro release showed that an increasing NB-HP-β-CD concentration decreased the release rate of NB from the TCH, but the amount of NB released was more than 96% at 60 min, which showed the TCH had good release behavior. View Full-Text

Keywords: thermosensitive composite hydrogel; phase transition temperature; mechanical properties; rheological properties; release behavior thermosensitive composite hydrogel; phase transition temperature; mechanical properties; rheological properties; release behavior





Autor: Jianping Chen, Rong Zhou, Lin Li, Bing Li, Xia Zhang and Jianyu Su *

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados