Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium CompoundsReport as inadecuate




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1

Department of Chemistry, Physics and Environment, Faculty of Science and Environment -Dunarea de Jos- University of Galati, 111 Domneasca Street, 800201 Galati, Romania

2

Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering -Dunarea de Jos- University of Galati, 111 Domneasca Street, 800201 Galati, Romania

3

Centre National de la Recherche Scientifique CNRS, UMR 5063, Department of Molecular Pharmacochemistry, F-38041 Grenoble, France

4

Department of Molecular Pharmacochemistry, University of Grenoble-Alpes, F-38041 Grenoble, France





*

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Abstract A series of bis-pyridinium quaternary ammonium salts bis-PyQAs with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations MIC. The relationships between the structure descriptors logP, polarizability, polar surface area 2D, van der Waals area 3D and the biological activity of the tested bis-PyQAs are discussed. View Full-Text

Keywords: pyridinium quaternary salts; antimicrobial activity; 4-2-pyridin-4-ylethylpyridine, 4,4-bipyridine pyridinium quaternary salts; antimicrobial activity; 4-2-pyridin-4-ylethylpyridine, 4,4-bipyridine





Author: Bianca Furdui 1, Georgiana Parfene 2, Ioana Otilia Ghinea 2, Rodica Mihaela Dinica 1,* , Gabriela Bahrim 2 and Martine Demeunynck 3,4

Source: http://mdpi.com/



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