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Department of Oncological Surgery, Hangzhou First Peoples Hospital, Hangzhou 310006, China


Department of General Surgery, Wuxi Second Peoples Hospital, Wuxi 214000, China


Department of Oncological Surgery, Wushan District of Hangzhou First Peoples Hospital, Hangzhou Cancer Hospital, Hangzhou 310002, China

These authors contributed equally to this work.


Author to whom correspondence should be addressed.

Abstract This study screened microRNAs miRNAs that are abnormally expressed in papillary thyroid carcinoma PTC tissues to identify PTC and nodular goiter and the degree of PTC malignancy. A total of 51 thyroid tumor tissue specimens paired with adjacent normal thyroid tissues were obtained from the Department of Surgical Oncology of Hangzhou First People’s Hospital from June-December 2011. miRNA expression profiles were examined by microarrays and validated by quantitative real-time PCR qRT-PCR. Expression levels of the miRNAs were analyzed to assess if they were associated with selected clinicopathological features. Eleven miRNAs were significantly differentially expressed between nodular goiter and PTC and between highly invasive and low invasive PTC. miR-199b-5p and miR-30a-3p were significantly differentially expressed among the three groups. miR-30a-3p, miR-122-5p, miR-136-5p, miR-146b-5p and miR-199b-5p were selected for further study by qRT-PCR and miR-146b-5p, miR-199b-5p and miR-30a-3p were different between the PTC and nodular goiter groups. miR-199b-5p was over-expressed in PTC patients with extrathyroidal invasion and cervical lymph node metastasis. In conclusion miR-146b-5p, miR-30a-3p, and miR-199b-5p may serve as biomarkers for the diagnosis of PTC and miR-199b-5p is associated with PTC invasiveness. View Full-Text

Keywords: papillary thyroid carcinoma; miRNA; invasiveness papillary thyroid carcinoma; miRNA; invasiveness

Autor: You Peng 1,†, Chen Li 2,†, Ding-Cun Luo 3,* , Jin-Wang Ding 1, Wo Zhang 1 and Gang Pan 1



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