Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureusReportar como inadecuado




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1

Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

2

Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China





*

Author to whom correspondence should be addressed.



Abstract In this study, we report the antibacterial activities of six polyphenols i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol against 29 clinical isolates of methicillin-resistant Staphylococcus aureus MRSA, and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects. View Full-Text

Keywords: methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism





Autor: Yanli Su 1, Liyan Ma 2, Yan Wen 1, Hong Wang 1 and Shuwen Zhang 1,*

Fuente: http://mdpi.com/



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