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1

Nanophysics Department, Istituto Italiano di Tecnologia IIT, via Morego 30, Genova 16163, Italy

2

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest 011061, Romania

3

Microbiology and Immunology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor, No. 1-3, Bucharest 060101, Romania



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Abstract This review highlights the current situation of antimicrobial resistance and the use of magnetic nanoparticles MNPs in developing novel routes for fighting infectious diseases. The most important two directions developed recently are: i improved delivery of antimicrobial compounds based on a drastic decrease of the minimal inhibition concentration MIC of the drug used independently; and ii inhibition of microbial attachment and biofilm development on coated medical surfaces. These new directions represent promising alternatives in the development of new strategies to eradicate and prevent microbial infections that involve resistant and biofilm-embedded bacteria. Recent promising applications of MNPs, as the development of delivery nanocarriers and improved nanovehicles for the therapy of different diseases are discussed, together with the mechanisms of microbial inhibition. View Full-Text

Keywords: infectious diseases; antimicrobials; antibiotics; magnetic nanoparticles; drug delivery infectious diseases; antimicrobials; antibiotics; magnetic nanoparticles; drug delivery





Autor: Ioannis Liakos 1,†,* , Alexandru Mihai Grumezescu 2,†,* and Alina Maria Holban 2,3,†,*

Fuente: http://mdpi.com/



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