Hepatoprotective Triterpene Saponins from the Roots of Glycyrrhiza inflataReportar como inadecuado




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1

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

2

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China

3

Translational Medicine Research Center of Nanjing University of Chinese Medicine, Nanjing 210023, China





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Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Two novel oleanane-type triterpene saponins, licorice-saponin P2 1 and licorice-saponin Q2 3, together with nine known compounds 2, 4–11, have been isolated from the water extract of the roots of Glycyrrhiza inflata. The structures of these compounds were elucidated on the basis of spectroscopic analysis, including 2D-NMR experiments 1H–1H COSY, HSQC, HMBC and ROESY. In in vitro assays, compounds 2–4, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine D-GalN. In addition, compounds 2–4, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 μM, 3.6 μM, 16.9 μM, 27.1 μM, 32.2 μM and 9.3 μM, respectively, which might be involved in the regulation of the hepatoprotective activities observed. View Full-Text

Keywords: Glycyrrhiza inflate; genus Glycyrrhiza; triterpene saponin; hepatoprotective; phospholipase A2 Glycyrrhiza inflate; genus Glycyrrhiza; triterpene saponin; hepatoprotective; phospholipase A2





Autor: Yun-Feng Zheng 1,2, Juan-Hua Wei 1, Shi-Qi Fang 1, Yu-Ping Tang 1,2, Hai-Bo Cheng 3, Tian-Lin Wang 1, Cun-Yu Li 1,2 and Guo-Ping Peng 1,2,*

Fuente: http://mdpi.com/



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