Synthesis, Photophysical Characterization, and Photoinduced Antibacterial Activity of Methylene Blue-loaded Amino- and Mannose-Targeted Mesoporous Silica NanoparticlesReportar como inadecuado




Synthesis, Photophysical Characterization, and Photoinduced Antibacterial Activity of Methylene Blue-loaded Amino- and Mannose-Targeted Mesoporous Silica Nanoparticles - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain



These authors contributed equally to this work.





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Academic Editor: Peter J. Rutledge

Abstract Over the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy aPDT, also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. We have explored the effectiveness of methylene blue-loaded targeted mesoporous silica nanoparticles MSNP in the photodynamic inactivation of two Gram negative bacteria, namely Escherichia coli and Pseudomonas aeruginosa. For E. coli, nanoparticle association clearly reduced the dark toxicity of MB while preserving its photoinactivation activity. For P. aeruginosa, a remarkable difference was observed between amino- and mannose-decorated nanoparticles. The details of singlet oxygen production in the nanoparticles have been characterized, revealing the presence of two populations of this cytotoxic species. Strong quenching of singlet oxygen within the nanoparticles is observed. View Full-Text

Keywords: antimicrobial photodynamic therapy aPDT; singlet oxygen 1O2; mesoporous silica nanoparticle MSNP; methylene blue; drug delivery system; mannose; E. coli; P. aeruginosa antimicrobial photodynamic therapy aPDT; singlet oxygen 1O2; mesoporous silica nanoparticle MSNP; methylene blue; drug delivery system; mannose; E. coli; P. aeruginosa





Autor: Oriol Planas †, Roger Bresolí-Obach †, Jaume Nos †, Thibault Gallavardin, Rubén Ruiz-González, Montserrat Agut and Santi Nonell *

Fuente: http://mdpi.com/



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