Four New Pentasaccharide Resin Glycosides from Ipomoea cairica with Strong α-Glucosidase Inhibitory ActivityReportar como inadecuado




Four New Pentasaccharide Resin Glycosides from Ipomoea cairica with Strong α-Glucosidase Inhibitory Activity - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

School of Traditional Chinese Medicinal Chemistry, Guangdong Pharmaceutical University, Guangzhou 510006, China



These authors contributed equally to this work.





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Academic Editor: Derek J. McPhee

Abstract Six pentasaccharide resin glycosides from Ipomoea cairica, including four new acylated pentasaccharide resin glycosides, namely cairicoside I–IV 1–4 and the two known compounds cairicoside A 5 and cairicoside C 6, were isolated from the aerial parts of Ipomoea cairica. Their structures were established by a combination of spectroscopic, including two dimensional 2D NMR and chemical methods. The core of the six compounds was simonic acid A, and they were esterfied the same sites, just differing in the substituent groups. The lactonization site of the aglycone was bonded to the second saccharide moiety at C-2 in 1–4, and at C-3 in 5–6. Compounds 1 and 5, 4 and 6 were two pairs of isomers. The absolute configuration of the aglycone in 1–6 which was 11S-hydroxyhexadecanoic acid jalapinolic acid was established by Mosher’s method. Compounds 1–4 have been evaluated for inhibitory activity against α-glucosidase, which all showed inhibitory activities. View Full-Text

Keywords: Ipomoea cairica; resin glycoside; simonic acid A; α-glucosidase Ipomoea cairica; resin glycoside; simonic acid A; α-glucosidase





Autor: Jie-Tao Pan †, Bang-Wei Yu †, Yong-Qin Yin * , Jie-Hong Li, Li Wang, Li-Bing Guo and Zhi-Bin Shen

Fuente: http://mdpi.com/



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