Cytotoxic Lignan from the Non-Transformed Root Culture of Phyllanthus amarusReportar como inadecuado




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1

Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, Gdańsk 80-210, Poland

2

Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk 80-822, Poland

3

NMR Laboratory, Faculty of Chemistry, Technical University of Gdańsk, Gdańsk 80-233, Poland





*

Author to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract A new lignan from the non-transformed root in vitro cultures of Phyllanthus amarus was isolated. The structure of the compound was established on the basis of one- and two-dimensional NMR, as well as mass spectrometry data, as 7-oxocubebin dimethylether 1,4-bisbenzod1,3dioxol-5-yl-2,3-bismethoxymethylbutan-1-on. The non-transformed root cultures of P. amarus showed to be a selective source of this compound. The lignan revealed strong cytotoxic activity against HeLa cell line with an IC50 value of 3.8 µg-mL. View Full-Text

Keywords: Phyllanthus amarus; 7-oxocubebin dimethylether; cytotoxic activity; in vitro culture Phyllanthus amarus; 7-oxocubebin dimethylether; cytotoxic activity; in vitro culture





Autor: Barbara Sparzak 1, Mirosława Krauze-Baranowska 1,* , Anna Kawiak 2 and Paweł Sowiński 3

Fuente: http://mdpi.com/



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